Maine is about 2.2 times smaller than Missouri.

Missouri is approximately 178,414 sq km, while Maine is approximately 79,931 sq km, making Maine 44.8% the size of Missouri. Meanwhile, the population of Missouri is ~6.0 million people (4.7 million fewer people live in Maine).
This to-scale comparison of Missouri vs. Maine uses the Mercator projection, which distorts the size of regions near the poles. Learn more.

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